Drug Gene Tool Demo App Guide

Introduction

Drug Gene Tool Demo App is a single page web app to demonstrate the capabilities of KGrid and CPIC Knowledge Objects (opens new window).

The app connects with the KGrid Sandbox instances of Activator (opens new window) and interacts with the activated Knowledge Objects.

The app also integrates with SMART Sandbox STU3; therefore, the SMART launcher is needed to run the app. After launching and selecting the patient, the app interface will be displayed.

Usage

• Choose one of five autofill sample data sets;

• The app will load the sample patient data;

• The phenotypes will be determined by the geno-to-pheno Knowledge Objects and displayed along with the input dipltotypes

• Based on the genetic information, a list of drugs with available recommendation will be displayed. Select the drug on interest, the dosing recommendation will be computed using the dosing recommendation Knowledge Objects.

Note:

1. This demo app uses a previous release of the CPIC collection. The link to current CPIC collection documentation is for reference only.

2. In the phenotype panel, the links of Knowledge Link (will appear when flipped) will direct to the geno-to-pheno Knowledge Objects in Kgrid Library (opens new window);

3. In the recommendation panel, the links of Knowledge Link (will appear when flipped) will direct to the dosing recommendation Knowledge Objects in Kgrid Library (opens new window);

4. Patient data can be manually adjusted and the phenotype results can be recalculated.